Dose-Response Relationship (16 points)You were hired by a pharmaceutical company to study a new blood thinner. To understand dose-responserelationship of this medicine, you conducted an experiment in rabbits. You decided to generate a bloodclot in rabbit’s ears and see if the injection of this blood thinner into the blood can help dissolve the clot.So, the left ear of rabbits were injected with coagulant and blood clots were formed. Two hours later, allrabbits were injected with this blood thinner and responses were recorded.

Table 1 recorded effective doses and # of response to the blood thinner. However, rabbits began to sufferhemorrhage (bleeding) with the exposure dose equal or higher than 40 mg/kg.

Table 2 recordedlethal/toxic doses and # of response to the blood thinner.

Would you suggest your company to sell this blood thinner? You need to complete the following to getthe answer:

(1) Complete cumulative % response calculations (4 pts)

(2) plot a % cumulative-response curve for effective response, and a % cumulative-responsecurve for lethal/toxic response on the same graph. (3×2 = 6 pts)

(3) Answer the questions after you plot the curves. (3×1 + 3 = 6 pts)